Inactive Ingredients: Dimethyl isosorbide, unstabilized glycerol formal, and butylated hydroxytoluene.
Usage: For additional information, please contact your veterinarian or refer to the full prescribing information provided in the manufacturer's package insert. NexGard COMBO should be applied topically as directed by your veterinarian. Please consult your veterinarian before making any changes or discontinuing the prescribed dosing schedule. Manufacturer Dosage Instructions: NexGard COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is dosed at a minimum of 0.055 mL⁄lb. (0.12 mL⁄kg), which delivers a minimum dose of 0.65 mg⁄lb. (1.44 mg⁄kg) esafoxolaner, 0.22 mg⁄lb. (0.48 mg⁄kg) eprinomectin, and 4.53 mg⁄lb. (9.98 mg⁄kg) praziquantel. Administer the entire contents of a NexGard COMBO unit applicator topically once a month. For heartworm disease prevention, apply once monthly for at least three months after last exposure to mosquitoes.
1. Use scissors to cut the blister along the dotted line.
2. Then pull the lid away.
3. Remove the applicator from the package and hold it upright. Pull back the plunger slightly.
4. Twist and pull off the cap.
5. Part the hair on the midline of the neck, between the base of the skull and the shoulder blades, until the skin is visible. Place the tip of the applicator on the skin and apply the entire contents directly onto the skin in one spot. The product should be applied to dry skin on an area where the cat cannot lick it off. If the weight of the cat requires a second application, apply the contents in the same manner as described above in the same location.
6. Wash hands after use with soap and water.
Missed Doses: If a dose is missed: Administer NexGard COMBO immediately and resume a monthly dosing schedule. Do not apply more medication than prescribed or two doses at once. If you have questions about your pet's prescribed dosing schedule (e.g., missed doses, timing, interval), please consult your veterinarian.
Side Effects: The most frequently reported side effects of NexGard COMBO include vomiting, application site reactions (e.g., redness, hair changes, itching), lethargy, and anorexia (decrease or loss of appetite). If ingested, hypersalivation (excessive drooling) may occur. Contact your veterinarian immediately if your pet has a seizure or any other neurologic adverse reaction (e.g., tremors, loss of coordination), or if any signs of a hypersensitivity reaction (e.g., hives, swelling) occur. This may not be a complete list of possible side effects; for more information, please contact your veterinarian or refer to the manufacturer package insert. Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome. If you notice anything unusual, please consult your veterinarian.
Precautions: Before using this product, please review the product label and package insert for important safety information, including any relevant warnings and precautions. For topical use on cats only. Not for human use. Keep this and all drugs out of sight and reach of children. Avoid direct contact with the application site for 4 hours or until visibly dry. This product may act as a mild to moderate eye irritant. If the product accidentally gets into the eyes, rinse thoroughly with water. If wearing contact lenses, flush the eyes first with water and then remove the lenses and continue to flush thoroughly with water. In case of accidental ingestion, or if skin or eye irritation occurs, contact a poison control center or physician for treatment advice. Keep product in the original packaging until use. Wash hands after product administration. Esafoxolaner, one of the ingredients in NexGard COMBO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in cats receiving isoxazoline class drugs, even in cats without a history of seizures. Use with caution in cats with a history of seizures or neurologic disorders. Do not administer orally. Cats may salivate excessively if NexGard COMBO is accidentally administered orally or is ingested through licking⁄grooming the application site.
The safety of NexGard COMBO has not been tested in kittens less than 8 weeks of age or weighing less than 1.8 lbs., or in breeding, pregnant, or lactating cats. Do not apply NexGard COMBO on cats with a known or suspected allergy⁄hypersensitivity to it or any of its ingredients. Allergic reactions to medications may occur. Please inform Vetsource and your veterinarian if your pet has any known sensitivities or allergies, especially to medications and suppleme
